Publications
Falk M. 2001. Myotonic dystrophy and trinucleotide expansions. Inf. listy společnosti J.G. Mendela, 23: 24-41 (article in Czech)
Falk M., Lukášová E., Kozubek S., Kozubek M. 2002. Topography of genetic elements of X-chromosome relative to the cell nucleus and to the chromosome X territory determined for human lymphocytes. Gene 292: 13-24
Kozubek S., Lukášová E., Jirsová P., Koutná I.,Kozubek M., Gaňová A., Bártová E., Falk M., Paseková R. 2002. 3D Structure of the Human Genome: Order in Randomness, Chromosoma 111: 321-331
Lukášová E., Kozubek S., Kozubek M.,Falk M., Amrichová J. 2002. The 3D structure of human chromosomes in cell nuclei. Chrom Res. 10: 535-548
Falk M, FrosterU. and Vojtíšková M. 2003. Methodological Possibilities for the Determination of the Number of CTG/CAG Repeats in Triplet Repeat Units of the Human Genome. Cas Lek Cesk. 142, 10: 513-518 (article in Czech)
Lukášová E., Kozubek S., Falk M., Kozubek M., Žaloudík J., Vagunda V., Pavlovský Z. 2003. Topography of genetic loci in the nuclei of cells of colorectal carcinoma and adjacent tissue of colonic epithelium. Chromosoma 112(5):221-30
Rittich B., Španová A., Falk M., Benes M.J., Hruby M., 2004. Cleavage of double stranded plasmid DNA by lanthanide complexes. J Chromatogr B Analyt Technol Biomed Life Sci. 800(1-2): 169-73
Lukášová E., Kořistek Z., Falk M., Kozubek S., Grigoryev S., Kozubek M. and KroupovaI. 2005 (accepted for publication). Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities. J. Leuk. Biol. 77: 100-111
Falk M., Vojtísková M., Lukás Z., KroupováI., and FrosterU., 2006. Simple Procedure for Automatic Detection of Unstable Alleles in the Myotonic Dystrophy and Huntington's Disease Loci. Genetic Testing, Volume 10(2):85-97.
Ondřej V., Kozubek S., Lukášová E., Falk M., Matula Pa., Matula Pe., Kozubek M. 2006. Directional motion of foreign plasmid DNA to nuclear HP1 foci. Chrom Res. 14:505-514.
Falk M., Lukasova E., Gabrielova B., Ondrej V., Kozubek S. 2007.Chromatin dynamics during DSB repair. Biochim Biophys Acta 1773(10):1534-45. Epub 2007 Jul 18. IF=6.9
Ondřej V., Lukášová E., Falk M., Kozubek S. 2007. The role of actin and microtubule networks in plasmid DNA intracellular trafficking. Acta Biochimica Polonica 54 (3):657-63.
Lukáš Z., KroupováI., Bednařík J., Falk M., Fajkusová L., Sedláčková J., Valášková I., Voháňka S. 2007. Muscular biopsy in myotonic dystrophy in the era of molecular genetics. Cesk Slov Neurol N. 70/103(4):395-401.
Falk M., Lukasova E., Gabrielova B., Ondrej V., Kozubek S. 2007-8. Local changes of higher-order chromatin structure during DSB-repair. Journal of Physics Conference Series 101 (2008) 012018, DOI: 10.1088/1742-6596/101/1/012018
Falk M., Lukasova E, Kozubek S. 2008. Chromatin structure influences the sensitivity of DNA to γ-radiation. Biochim Biophys Acta MCR, Article in Press. DOI: 10/1016/j.bbamcr.2008.07.010 IF=6.9
Dellino G.I., Falk M., Faretta M., Bucci G., De Santis F., Cesaroni M., Luzi L., Lukasova E., Segalla S., Alcalay M., Minucci S., Kozubek S. and Pelicci P.G. 2007-8. Higher-order chromatin changes induced by an oncogenic transcription factor. prepared for publication
Falk M., Lukasova E. and Kozubek S. 200X.Higher order chromatin structure in DSB induction, repair and misrepair. Mut Res Rev 2010, DOI 10.1016/j.mrrev.2010.01.013, in press (IF=5.912/ 5-years IF=6.091)
Other full-extenso publications:
Falk M., Lukášová E., Kozubek S., Kozubek M., Krasavin E.A. 2001. Topography of dystrophin exons relative to the cell nucleus and to the active and inactive chromosome X territory determined for human lymphocytes. Proceedings from conference on Biophysics of the Genome and Its Interactions, p. 18-27, ISBN 80-210-2853-X (in English),
Kozubek S., Lukášová E., Bártová E., Koutná I., Jirsová P., Kozubek M., Gaňová A., Paseková R., Amrichová J., Falk M., Hložek P. 2001. Structure of the Human Genome: Experimental Results and Models. Proceedings from conference on Biophysics of the Genome and Its Interactions, p. 54-67, ISBN 80-210-2853-X (in English),
Lukášová E., Kozubek S., Kozubek M., Falk M., Jirsová P., Bártová E. 2001. Spatial Arrangement of Chromosome 17 Territory in the Interphase Nucleus of Human Lymphocytes. Proceedings from conference on Biophysics of the Genome and Its Interactions, p. 68-73, ISBN 80-210-2853-X (in English),
Falk M. 2000. Pathological states induced by trinucleotide repeat expansions. Molecular diagnostics of myotonic dystrophy. Diploma thesis, Masaryk University Brno, Faculty of Science (in Czech).
Falk M. 2003. Methodological Approaches for Determination of the Number of Triplet Repeat Units in Human Genome. Rigorous thesis, Masaryk University Brno, Faculty of Science (in Czech).
Falk M. 2004. Hypotheses on the relationship between higher-order chromatin structure and gene expression. Disertation thesis, Masaryk University Brno, Faculty of Science (in Czech).
Falk M., Lukasova E., Faretta M., Dellino I., Kozubek S., Pelicci PG., Kozubek M., Rochi M. Colocalization of PML bodies and PML/RARalpha microspeckles with up- and down-regulated loci and changes of chromatin structure in APL leukemia cells. In Biophysics of the Genome. Vyd. First Edition 2004.
Falk M., Šilhánová E., GrochováI. and Vojtíšková M. 2000. Stable and unstable trinucleotide CTG repeat alleles in myotonic dystrophy locus. J Biomol Struct & Dyn. 17, 6: 1162
Vojtíšková M., Falk M., Vytopil J., Enzmann G., Froster U., Gaillyová R. 2000. PCR methods for detection of large trinucleotide repeat expansions. Scr Med. 73, 4: 265-266
Gaňová A., Lukášová E., Kozubek S., Kozubek M., Bártová E., Jirsová P., Skalníková M., Koutná I., Paseková R., Falk M. 2001. Exchange Aberrations among 11 Chromosomes of Human Lymphocytes Induced by g-Rays. Acta Radiobiol. 1: 21
Falk M., Gaillyová R. and Vojtíšková M. 2001. Use of New Modified PCR-based Methods for Rapid Differential Diagnostics of Myotonic Dystrophy. Eur J Mol Genet. 9, suppl. 1: 209
Vojtíšková M., FrosterU., Enzmann G., Falk M., Šilhánová E. 2002. Determination of CTG repeats: Unstable alleles in Myotonic Dystrophy locus. In 13th Annual Meeting of German Society of Human Genetics, Sept 29th 2002, Leipzig, Germany. Medizinische Genetik 3: 351
Falk M., Vojtíšková M., Froster U. 2003. Methodological possibilities for the determination of the number of CTG/CAG repeats in triplet repeat units of the human genome. Analytical Cellular Pathology
Falk M., Lukasova E., Kozubek S., Pellici G.I., Faretta M., Kozubek M., Rocchi M. 2003. Changes in gene expression induced by PML/RARa fusion protein correlate with the degree of chromatin compaction. Analytical Cellular Pathology
Kozubek S., Lukášová E., Bártová E., Kozubek M., Amrichová, J., Falk M., Ondřej V. 2003. Detailed studies of the 3D structure of chromosome territories. European Cytogenetics Conference /4./. Bologna (IT), Annales de Génétique, 46 [2-3] 77-78.
Kozubek S., Bartova E., Lukasova E., Kozubek M., Amrichova J., Taslerova R., Falk M., Ondrej V. 2003. Large-scale organization of human genome and chromosomal territories in the nucleus of normal and cancer cells and its functional implications. Analytical Cellular Pathology
Kozubek S., Lukášová E., Bártová E., Kozubek M., Amrichová J.,Falk M., Ondøej V. 2003. Detailed studies of the 3D structure of chromosome territories. Annales de Génétique, 46 (2-3): 77-78.
Falk M., KroupováI., Vojtíšková M., Lukáš Z. 2005. New trends in molecular diagnostics and pathogenesis of myotonic dystrophy. Čes a Slov neurologie a neurochirurgie
Kozubek S., Bártová E., Lukášová E., Falk M., Ondřej V., Kozubek M, Kroupová J., Matula P and Matula Pe. 2006. High-Resolution cytometry represents the main technology used in the laboratory of molecular cytology and cytometry. Cell proliferation in basic and clinical sciences,39(5):341.
Lukas Z., Kroupova I., Falk M., Valaskova I., Fajkusova L., Sedlackova J. 2007. RNA fluorescence in situ hybridization analysis of fetal tissues affected by myotonic dystrophy. Neuromuscular Disorders, 17 (9-10):856
Falk M., Vojtíšková M., Gaillyová R. 2000. Methodological Possibilities for detection of expanded trinucleotide repeats in myotonic dystrophy locus. Abstracts from IV. Workshop of Biochemists an Molecular Biologists, Brno, 9. February 2000, ČR: p. 84-85 (ISBN 80-210-2266-3).
Falk M., Šilhánová E., GrochováI. and Vojtíšková M. 2000. Stable and unstable trinucleotide CTG repeat alleles in myotonic dystrophy locus. In Conference on DNA structure and interactions - Mendel – Brno 2000, July 19-23 2000: Brno, ČR. Book of Abstracts D-24
Falk M., Vojtíšková M. 2000. Detection of expanded triplets in myotonic dystrophy locus. Book of Abstracts, 4. Natinal conference on DNA diagnostics with international participation, Praha, 13.-14. 12. 2000 [online] - http://www.uhkt.cz/forms/konfsel.sqw
Falk M., Gaillyová R. and Vojtíšková M. 2001. Use of new modified PCR-based methods for rapid differential diagnostics of myotonic dystrophy. Abstracts from V. Workshop of Biochemists an Molecular Biologists, Brno, 14. 2. 2001, ČR: p. 35b (ISBN 80-210-2538-7).
Vojtíšková M., Falk M., Oltová A., Žáková J., Vodinská M., Ventruba P. 2001. Application of fluorescent quantitative PCR methods in prenatal diagnostics. In XVI. Days of Biology, 5.-7. 9. 2001, Olomouc, ČR: p. 29.
Falk M., Lukášová E., Kozubek S., Kozubek M., Krasavin E.A. 2002. Topography of dystrophin exons relative to the cell nucleus and to the active and inactive chromosome X territory determined for human lymphocytes. Abstracts from conference on Biophysics of the Genome and Its Interactions, October 15 – 17, 2001, Hlohovec, Czech Republic
Kozubek S., Lukášová E., Bártová E., Koutná I., Jirsová P., Kozubek M., Gaňová A., Paseková R., Amrichová J., Falk M., Hložek P. Structure of the Human Genome: Experimental Results and Models. 2001. Abstracts from conference on Biophysics of the Genome and Its Interactions, October 15 – 17, 2001, Hlohovec, Czech Republic
Lukášová E., Kozubek S., Kozubek M., Falk M., Jirsová P., Bártová E. 2001. Spatial Arrangement of Chromosome 17 Territory in the Interphase Nucleus of Human Lymphocytes. 2001. Abstracts from conference on Biophysics of the Genome and Its Interactions, October 15 – 17, 2001, Hlohovec, Czech Republic
Falk M, Španová A., Rittich B. 2002. Interactions of metal ions with immobilized DNase I. In VI. Workshop of biochemists and molecular biologists, February 2002, Brno, ČR: p. 28-29 (ISBN 80-210-2777-0).
Falk M., Lukášová E., Kozubek S., Kozubek M. Topography of genetic elements of X-chromosome relative to the cell nucleus and to the chromosome X territory determined for human lymphocytes. Abstracts from the 2nd Elmau Conference on Nuclear Organization, Gene Regulation and Nuclear Structure. October 6-9, 2002, Schloss Elmau, Germany
Španová A., Rittich B., Falk M. 2002. Degradation of plasmid and high-molecular weight DNAs by lanthanide ions. In 22nd International Symposium on the Separation of Proteins, Peptides and Polynucleotides. Heidelberg, Germany : Dechema, 2002., Book of Abstracts p. 51-51-51.
Rittich B., Španová A., Falk M., Beneš M., Hrubý M. 2003. Cleavage of double stranded plasmid DNA by lanthanide complexes. In 3rd International Symposium on Separations in BioSciences SBS 2003, 100 Years of Chromatography. Moskva, Russian Academy of Sciences, 2003. p. 126-126.
Falk M., Lukášová E., Faretta M., Dellino I., Kozubek S., Pellici G.I., Kozubek M., Rocchi M. 2003. Colocalization of PML bodies and PML/RARa microspeckles with up- and down-regulated loci and changes of chromatin structure in APL leukemia cells. In Third Workshop on Biophysics of the Genome, 12-13 October 2003, Brno, Czech Republic.
Lukášová E., Kozubek S.,Falk M., Kozubek M., Žaloudík J., Vagunda V., Rocchi M., Pavlovský Z. 2003. Organization of selected loci of chromosomes 7,11, and 20 in cells colorectal carcinoma and adjacent colonic tissue. In: Scientific Programme and Book of Abstracts, Conference on Biophysics of the Genome, Hlohovec, Czech Republic.
Lukášová E., Falk M., Kořistek Z., Kozubek S., Grigoryev S., Kozubek M., Ondřej V., Kroupová I. 2003. Methylation of histone H3K9 on lysine 9 distinguishes granulocytes of healthy individuals and patients with myeloid leukemia. In Third Workshop on Biophysics of the Genome, 12-13 October 2003, Brno, Czech Republic.
Kozubek S., Bártová E., Lukášová E., Kozubek M., Amrichová J., Taslerová R.,Falk M., Ondřej V. Large scale organization of the human genome and chromosomal territories in the nucleus of normal and cancer cells and its functional implications. In: International Conference on Applied Genomics. Proceedings. - Amsterdam, - 2003. - p. 73. [International Conference on Applied Genomics (ESACP /9./ - ISDQP Meeting /16./). Amsterdam (NL)
Falk M., Lukášová E., Faretta M., Dallino I., Kozubek S., Pellici G.I., Kozubek M., Rocchi M. 2005. Changes of nuclear architecture and chromatin structure induced by PML/RARa fusion protein in APL leukemic cells. In Third Conference on Analytic Cytometry, 21.-25. June 2005, Červenohorské sedlo, Czech Republic.
Falk M., Lukášová E., Gabrielová B, KroupováI. and Kozubek S. Nuclear Organization and Dynamics of the DSB-repair − Direct Visualization of Double Strand Breaks in Functionally Different Chromatin Domains. In The Program and Abstracts of Papers Presented at the Salk Institute, Nature and Fondation IPSEN Conference on Biological Complexity: Diseases of Transcription. January 11-14, 2007, Salk Institute, La Jolla, CA, USA, p:46.
Pelicci P.G. (results of Falk M., Lukášová E. and Kozubek S. included): Effects on Oncogenic Fusion Proteins on Chromatin. Salk Institute, Nature and Fondation IPSEN Conference on Biological Complexity: Diseases of Transcription. In The Program and Abstracts of Papers Presented at the Salk Institute, Nature and Fondation IPSEN Conference on Biological Complexity: Diseases of Transcription. January 11-14, 2007, Salk Institute, La Jolla, CA, USA, p:28.
Falk M., Lukášová E., Gabrielová B., Ondřej V., Kozubek S. Local changes of higher-order chromatin structure during DSB-repair. In RADAM Conference 2007 – Radiation Damage in Biomolecules Conference. June 19-22, 2007, Dublin, Ireland.
Dellino I.G., Falk M., Lukášová E., Faretta M., Pelicci P.G., Kozubek S. PML/RARa fusion oncoprotein, new mechanisms of gene downregulation in leukemia and aimed therapy. In Analytical Cytometry IV, July 23-26, 2007, Brno, Czech Rep.